Early detection and diagnosis

Project 1:  Circulating tumour DNA in bloods of colorectal cancer patients (Academic Collaboration)

Project 2:  Serum spectroscopy for early cancer detection (Industry Collaboration)

Project 3Faecal pellet sensor development (Academic Collaboration)

Project 4:  Research collaboration to conjugate the CEA affirmer to an organic nanoparticle for the purpose of intra-operative colorectal cancer diagnosis. (Industry Collaboration)

Project 5:  Immuno-oncology applications of live, attenuated Salmonella (Industry Collaboration)

Project 6:  Volatile Biomarker Testing In Symptomatic Colorectal Patients study (Clinically-led study)

Project 7:  Lymph node detection in rectal cancer (Clinically-led study)

Project 8Finding Evidence to Treat Or Reassure in Appendicitis – FETOR study (Clinically-led study)

Project 9:  Anastomotic Leakage Device Development (Industry Collaboration)

Project 10The Groin wound Infection after Vascular Exposure (GIVE) Audit

Project 11:  An Exploratory Umbrella Study Investigating the Potential of a Rectal Mucus Sample for Development of Biomarker Assays in Subjects with Colorectal Cancer and other Gastro-intestinal Diseases (Industry Collaboration)

Project 12:  Diagnosis of OsteoMyelitis: INvestigation Optimisation in Diabetic Foot Ulcers (DOMINO-DFU) (Academic Collaboration)

Project 13:  Coupling Highly Fluorescent Conjugated Polymer Nanoparticles (CPNs) to Cancer-Specific Affirmers for the Early Detection and Precision Treatment of Colorectal Cancer (Academic Collaboration)

Project 14PreCisE: A Precision laser scalpel for Cancer diagnostics and Eradication (Academic Collaboration)

Project 15Terabotics – terahertz robotics for surgery and medicine (Academic Collaboration)

Enhancing treatment decisions

Project 1:  Patient and public involvement input for HEPARIM study – use of functional MRI for assessment of regional liver function (Academic Collaboration)

Project 2:  Microsatellite instability sporadic colon cancer study looking at whether we can detect any differences using Raman between microsatellite stable and unstable cancers (Academic Collaboration)

Project 3:  Laser Speckle Imaging (LSI) assessment of vascular reconstruction (Industry Collaboration)

Project 4:  Innovative solution for Polyp-lifting (Industry Collaboration)

Project 5:  Modelling the Human Gut Microbiome (Academic Collaboration)

Project 6:  Novel Lifesaving Magnetic Tentacles (Academic Collaboration)

Project 7:  Predicting brain tumour treatment response in a clinical timeframe to inform clinicians’ and patients’ decision making (Clinical Collaboration)

Project 8:  A bench-top personalised ‘mini-brain’ test that predicts brain cancer treatment response (Academic Collaboration)

Pre-operative (before surgery)

Project 1:  The impact of information design on the quality of bowel preparation for colonoscopy screening (Clinically-led study)

Project 2Developing a core outcome set (COS) for new surgeries and surgical devices – COHESIVE study (Academic Collaboration)

Intra-operative (during surgery)

Project 1:  Understanding the Biomechanics of Surgical Stapling (Industry Collaboration)

Project 2:  Steerable probe for fistula-in-ano surgery (Industry Collaboration)

Project 3:  Fistula Valve product development (Industry Collaboration)

Project 4Commercial Translation of an Intra-Abdominal Platform (IAP) for Next Generation Laparoscopic Surgery (Clinically-led study)

Project 5:  Development of device to prevent needle-stick injuries (Industry Collaboration)

Project 6:   Smart Checklist for Surgery (Industry Collaboration)

Project 7A fluorescence guided steerable laser tool for precision resection of early stage cancers (Academic Collaboration)

Project 8:  Intraoperative Florescence Angiography (IFA) to Prevent Anastomosis Leak in Rectal Cancer Surgery (Clinically-led study)

Project 9:  Medical Capsule Robots for painless colonoscopy (Academic Collaboration)

Project 10:  Prospective multicentre open clinical study to assess the safety performance and durability of the TIES® transcutaneous titanium implant in patients requiring a permanent ileostomy (Industry Collaboration)

Project 11:  Consortium To Develop Guidelines For Evaluating Surgical Robots (Academic Collaboration)

Project 12:  WHO Surgical Checklist App for use whilst wearing PPE (Clinically-led study)

Project 13:  New minimally invasive technologies for the treatment of pancreatic cancer (Academic Collaboration)

Project 14:  3D overlays into operating room for endovascular surgical guidance (Clinically-led study)

Project 15:  Using stem cells to reduce complications after bowel cancer surgery (Academic Collaboration)

Project 16:  Evaluation of microvascular anastomosis device (Industry Collaboration)

Project 17:  Development and Evaluation of Cell Therapy Scaffold Technology (Industry Collaboration)

Project 18:  Phase I study of gadolinium-based nanoparticle radiation dose amplification in rectal cancer (Clinically-led study)

Project 19:  Improving treatment outcomes and reducing costs in patients with enterocutaneous fistulas (Industry Collaboration)

Project 20: Augmented Reality Smart Surgical Glasses Evaluation (Industry Collaboration)

Project 21Surgery enabled by ultrasonics (Academic Collaboration)

Post-operative (after surgery)

Project 1:  Redesign of venous device (Clinically-led study)

Project 2Audit of wound infection following groin incision for vascular exposure in the United Kingdom (Clinically-led study)

Project 3TRACING study – Trial of Remote Continuous vs Intermittent Vital Signs Monitoring after Major Surgery (Industry Collaboration)

Project 4An investigation of transcutaneous vagal nerve stimulation on return of bowel function and inflammatory cytokines after colorectal surgery (Clinically-led study)

Project 5:  Omentum Derived Regenerative Cells (ODRCs) to prevent Anastomotic Leak following GI Surgery (Clinically-led study)

Project 6:  Clinical evaluation of rapid decontamination spray bottle (Industry Collaboration)

Project 7:  Observational study on sources and frequency of patient disturbance and its effect on post-surgical recovery (Clinically-led study)

Project 8:  Testing dietary app to support nutrition monitoring in NHS gastroenterology clinics (Industry Collaboration)

Project 9:  Smart Sensor Device to Prevent Bed Sores/Pressure Ulcers (Industry Collaboration)

Project 10:  A Multicenter Observational Registry to Develop Ablation Parameter Guidance for Microwave Liver Ablation (Industry Collaboration)

Project 11:  Electrochemotherapy  for patients with liver cancer (Industry Collaboration)

Project 12:  System for destruction of primary and metastatic liver tumours (Industry Collaboration)

Project 13:  Porous 3D Silica Nanoparticle Assemblies as Post-surgical Drug Delivery Implants to Reduce Glioblastoma Recurrence (Academic Collaboration)

Long term follow-up

Project 1:  Stretchy tape for faecal incontinence (Industry Collaboration)

Project 2:  A nationwide study of stoma care with health economic modelling (Industry Collaboration)

Project 3:  Raman spectroscopy for rectal patients to identify patients who will develop tumour regrowth (Clinically-led study) 

Project 4:   Jeans for Ostomates (Patient-led study)

Project 5:  Managing Venous Ulcers in Community during COVID-19 (Clinically-led study) 

Project 6:  Evaluation of device for patients with faecal incontinence (Industry Collaboration)

IMPRESS Projects

Project 1:

Kids Wearable Tech: Starting in 2018 and building on a range of workshops in collaboration with TITCH , we’ve seen huge enthusiasm from children, families and healthcare professionals in the early prototypes we’ve developed for a smart device app to help primary school aged children manage their continence issues. In 2019 we will continue to refine the design, working alongside Bristol University who are developing a similar aid for secondary school aged children.

Project 2:

Rethinking the Female Urinal: Working in conjunction with D4D and researchers at Bristol University we’ve been developing concepts and prototypes for improved female urinals. This is an area of huge unmet need and from our early work there is clear potential for innovations that could bring benefit in a range of circumstances.

Project 3:

Faecal Pellet Sensor: IMPRESS supported this early-stage technology development work which demonstrated the promise of enhanced sensing for the diagnosis of faecal incontinence and improved long term treatment. The technology is maturing and will now benefit from the support of the Surgical MedTech in moving towards pre-clinical evaluation.

Project 4:

IMechE Incontinence the Engineering Challenge XII: We’re excited to be involved in this conference. Dr Pete Culmer is co-organising the event alongside colleagues from across the IMPRESS network. More information here.